Chemicals 5-fluorouracil cas 51-21-8
| Payment Type: | L/C,T/T,Money Gram,Western Union |
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| Incoterm: | FOB,CIF |
| Min. Order: | 1 Kilogram |
| Delivery Time: | 3 Days |
| Packaging: | 1kg/bottle; 25kg/drum; 160kg/plastic drum |
|---|---|
| Productivity: | 1000kg per Month |
| Brand: | zhishang |
| Transportation: | Ocean,Land,Air |
| Place of Origin: | Shandong, China (Mainland) |
| Supply Ability: | in stock |
| Certificate: | ISO CE |
| HS Code: | 2933599090 |
| Port: | Shanghai,Qingdao,Tianjing |
Basic Info
Model No.: X-CAS 51-21-8
Product Description
Chemicals 5-fluorouracil cas 51-21-8
The use of methotrexate prior to 5-fluorouracil increases the formation of 5-fluorouracil nucleotides by increasing the content of intracellular phosphoribosyl pyrophosphate. Allopurinol alters the effects of fluorouracil, its metabolite, allopurinol, and inhibits orotate phosphoribosyltransferase, thus reducing toxicity and potentially improving the therapeutic index. Thymidine and other nucleosides increase the binding of fluorouracil to RNA, which can delay the breakdown of fluorouracil by dihydropyrimidine dehydrogenase. However, this combination has so far failed to significantly improve the clinical outcome.
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Product Analysis
Items Appearance Specifications White to off-white crystalline powder Results Conform Identification A. IR Conform B. UV Conform C. HPLC Conform Loss on drying ≤0.5% 0.06% Residue on ignition ≤0.1% 0.03% Heavy metals ≤20ppm Conform Impurities F and Urea (TLC method) Impurity F≤0.25% Conform Urea≤0.20% Conform Related substance (HPLC method) Impurity A≤0.25% <0.01% (LOD) Impurity B≤0.25% <0.01% (LOD) Uracil≤0.15% <0.01% (LOD) 5-Methoxyuracil≤0.15% 0.08% Impurity E≤0.25% <0.01% (LOD) Any individual unspecified impurity ≤0.10% Each<0.05% (disregard limit) Total≤0.5% 0.08% Assay (HPLC method) 98.0-102.0% 99.6% Bacterial endotomin ≤0.25 EU/mg Conform Mould and yeast count ≤100 cfu/g Conform Aerobic microbial count ≤1000 cfu/g Conform Escherichia coli Absent/g Absent/g Pseudomonas aeruginosa Absent/g Absent/g Staphylococcus aureus Absent/g Absent/g Conclusion The product meets the requirements of USP 37
Function and Application
5-Fluorouracil is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. It is metabolized to ribonucleotides and deoxyribonucleotides, which can be incorporated into RNA and DNA. Treatment of cells with 5-FU leads to an accumulation of cells in S-phase and has been shown to induce p53 dependent apoptosis.
1> Cosmetic Raw Materials: Cosmetics is a variety of raw materials through a reasonable deployment of processing from the compound mixture. Cosmetics with a wide range of raw materials, different performance. According to the raw material properties and uses of cosmetics, can be divided into matrix materials and auxiliary raw materials in two categories. The former is a class of cosmetics in the main raw materials, cosmetics in the possession of a large proportion of the cosmetics play a major role in the role of the material. The latter is the formation of cosmetics, stability or to give color, smell and other characteristics of the role of these substances in the cosmetic formula is not used, but it is extremely important. Cosmetics are natural, synthetic or extracted from the role of different substances as raw materials, by heating, mixing and emulsification and other production processes processed from the chemical mixture. 2> Active Pharmaceutical Ingredients(API): API refers to the raw materials in the production of various types of preparations, which is the active ingredient in powder,crystal and paste for medicine use through chemical synthesis,plant extract, and preparations of biotechnology institute.It is one substance or mixture during the medicine making period uut it can not be taken directly by patients. 3> Fragrance And Spices: Spice is a substance that can be scented by smelling or scented by taste, and is the raw material for the preparation of the fragrance. Spices are an important part of fine chemicals, it is composed of natural spices, synthetic spices and single fragrance. 4> Organic Raw Material: Intermediates are also known as organic intermediates. The use of coal tar or petroleum products as raw materials to produce dyes, pesticides, pharmaceuticals, resins, additives, and other intermediates. 5> Chemicals Used In Paints: Paint, the traditional Chinese name is paint. So-called coating is coated on the surface of the object that be protected or be adornment, and with the continuous film coating to form strong adhesion, usually in resin, or oil, or emulsion is given priority to, add or not add pigment, filler, add the corresponding additives, organic solvents or water preparation of viscous liquid. Product expansion
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Product Categories : Organic Intermediate > Pharmaceutical Intermediates